TRIB3 Polyclonal Antibody, Invitrogen™

Rabbit Polyclonal Antibody

Supplier:  Thermo Scientific PA141018

Catalog No. 01-676-636

Description

Suggested positive control: antigen standard for TRIB3 (transient overexpression lysate), human liver lysate, human liver protein.

A novel inhibitor of cell division, Tribbles, blocks mitosis at a critical point in Drosophila morphogenesis. Recently, mammalian homologues of Tribbles (Trbs) have been identified that control mitogen-activated protein kinase (MAPK) activity. TRIB3 also known as TRB-3, SINK, and SKIP3 is a member of Trbs family. Overexpression of this protein inhibits NF-kB-dependent transcription induced by tumor necrosis factor (TNF) stimulation or its downstream signaling proteins but does not inhibit NF-kB translocation to the nucleus and binding to DNA. TRIB3/SKIP3 is also overexpressed in multiple human tumors and is regulated by hypoxia.

Specifications

• Antigen: TRIB3
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: TRIB3
• Gene Alias: C20orf97; DJ1103G7.3; Ifld2; induced in fatty liver dystrophy 2; kinase; Neuronal cell death Inducible Putative Kinase; neuronal cell death-inducible putative kinase; Nipk; p65-interacting inhibitor of NF-kappaB; p65-interacting inhibitor of NF-kappa-B; SINK; SKIP3; Trb3; TRB-3; TRIB3; Tribbles 3; Tribbles homolog 3; tribbles homolog 3 (Drosophila); tribbles pseudokinase 3
• Host Species: Rabbit
• Purification Method: Protein G
• Regulatory Status: RUO
• Gene ID (Entrez): 57761
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunocytochemistry, Western Blot
• Concentration: 0.5 mg/mL
• Formulation: PBS with 0.05% BSA and 0.05% sodium azide
• Gene Accession No.: Q96RU7
• Gene Symbols: TRIB3
• Immunogen: Synthetic peptide corresponding to residues 315-332 of human TRIB3.
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov