TRIB3 Mouse anti-Human, Clone: OTI3C6, Invitrogen
Mouse Monoclonal Antibody
Manufacturer: Invitrogen MA526880
DescriptionA novel inhibitor of cell division, Tribbles, blocks mitosis at a critical point in Drosophila morphogenesis. Recently, mammalian homologues of Tribbles (Trbs) have been identified that control mitogen-activated protein kinase (MAPK) activity. TRIB3 also known as TRB-3, SINK, and SKIP3 is a member of Trbs family. Overexpression of this protein inhibits NF-kB-dependent transcription induced by tumor necrosis factor (TNF) stimulation or its downstream signaling proteins but does not inhibit NF-kB translocation to the nucleus and binding to DNA. TRIB3/SKIP3 is also overexpressed in multiple human tumors and is regulated by hypoxia.
|PBS with 1% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3|
|C20orf97, NIPK, SINK, SKIP3, TRB3, TRB-3, neuronal cell death inducible putative kinase, neuronal cell death-inducible putative kinase, p65-interacting inhibitor of NF-kappa-B, p65-interacting inhibitor of NF-kappaB, tribbles homolog 3|
|-20° C, Avoid Freeze/Thaw Cycles|
|Immunohistochemistry (Paraffin), Western Blot|
|Human recombit protein fragment corresponding to amino acids 1-200 of TRIB3 produced in E.coli|
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