Trifluoroacetic anhydride, 99+%, Thermo Scientific Chemicals

Description

Trifluoroacetic anhydride is used for the introduction of trifluoroacetyl group in organic synthesis. It is involved in the preparation of N- and O-trifluoroacetyl derivatives of a wide range of biologically active compounds for gas chromatography analysis. It plays an important role as desiccant for trifluoroacetic acid. It is also used in the oxidation of aldehydes to acids, esters, amides as well as in the protection of alcohols and amines. In addition, it is used as analytical reagents, solvents and dehydration condensing agent. It serves as an intermediate of fluorine fine chemicals, pharmaceuticals and agrochemicals.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Applications
Trifluoroacetic anhydride is used for the introduction of trifluoroacetyl group in organic synthesis. It is involved in the preparation of N- and O-trifluoroacetyl derivatives of a wide range of biologically active compounds for gas chromatography analysis. It plays an important role as desiccant for trifluoroacetic acid. It is also used in the oxidation of aldehydes to acids, esters, amides as well as in the protection of alcohols and amines. In addition, it is used as analytical reagents, solvents and dehydration condensing agent. It serves as an intermediate of fluorine fine chemicals, pharmaceuticals and agrochemicals.

Solubility
Miscible with benzene, dichloromethane, diethyl ether, dimethylformamide, terahydrofuran and acetonitrile.

Notes
Hygroscopic and moisture sensitive. Keep the container tightly closed in a dry and well-ventilated place. Incompatible with strong oxidizing agents, strong bases, strong acids, and alcohols.

Specifications

• Melting Point: -65°C
• Density: 1.503
• Boiling Point: 39°C to 40°C
• Refractive Index: 1.269
• Linear Formula: (CF₃CO)₂O
• Quantity: 25 g
• UN Number: UN3265
• Beilstein: 746197
• Sensitivity: Moisture sensitive
• Solubility Information: Miscible with benzene,dichloromethane,diethyl ether,dimethylformamide,terahydrofuran and acetonitrile.
• IUPAC Name: (2,2,2-trifluoroacetyl) 2,2,2-trifluoroacetate
• Formula Weight: 210.03
• Percent Purity: ≥99%
• Chemical Name or Material: Trifluoroacetic anhydride

Safety and Handling

Hazard Category	H314-H332-H335
Hazard Statement	GHS H Statement H314-H318-H332 Causes severe skin burns and eye damage. Causes serious eye damage. Harmful if inhaled.
Precautionary Statement	P260-P264b-P271-P280-P301+P330+P331-P303+P361+P353-P304+P340-P305+P351+P338-P310-P363-P501c
DOTInformation	Transport Hazard Class: 8; Packing Group: I; Proper Shipping Name: CORROSIVE LIQUID, ACIDIC, ORGANIC, N.O.S.
EINECSNumber	206-982-9
RTECSNumber	AJ9800000
TSCA	Yes
Recommended Storage	Keep cold; Store under Nitrogen

SDS

RUO – Research Use Only