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  6. Trimethylacetic anhydride, 99%, Thermo Scientific Chemicals

Trimethylacetic anhydride, 99%, Thermo Scientific Chemicals

Catalog Number AAB2298336
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Quantity:
25 g
100 g
500 g
1538-75-6
C10H18O3
186.25
MFCD00008842
PGZVFRAEAAXREB-UHFFFAOYSA-N
pivalic anhydride, trimethylacetic anhydride, 2,2-dimethylpropionic anhydride, propanoic acid, 2,2-dimethyl-, anhydride, pivalic anydride, 2,2-dimethylpropanoic anhydride, trimethylacetic acid anhydride, propanoic acid, 2,2-dimethyl-, 1,1'-anhydride, trimethylaceticanhydride, bispivalic anhydride
15234
2,2-dimethylpropanoyl 2,2-dimethylpropanoate
CC(C)(C)C(=O)OC(=O)C(C)(C)C
1538-75-6
C10H18O3
186.25
MFCD00008842
PGZVFRAEAAXREB-UHFFFAOYSA-N
pivalic anhydride, trimethylacetic anhydride, 2,2-dimethylpropionic anhydride, propanoic acid, 2,2-dimethyl-, anhydride, pivalic anydride, 2,2-dimethylpropanoic anhydride, trimethylacetic acid anhydride, propanoic acid, 2,2-dimethyl-, 1,1'-anhydride, trimethylaceticanhydride, bispivalic anhydride
15234
2,2-dimethylpropanoyl 2,2-dimethylpropanoate
CC(C)(C)C(=O)OC(=O)C(C)(C)C

Description

Trimethylacetic anhydride is used as acylation and esterification reagents. It is involved in acylation and esterification reactions with anilines and phenols. It is also used in solid-phase oligonucleotide synthesis and in the kinetic resolution of racemic 2-hydroxy-gamma-butyrolactones with diphenylacetic acid. It is also employed in the production of cyano-4, N-tert-butyloxycarbonyl piperidine.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Applications
Trimethylacetic anhydride is used as acylation and esterification reagents. It is involved in acylation and esterification reactions with anilines and phenols. It is also used in solid-phase oligonucleotide synthesis and in the kinetic resolution of racemic 2-hydroxy-gamma-butyrolactones with diphenylacetic acid. It is also employed in the production of cyano-4, N-tert-butyloxycarbonyl piperidine.

Solubility
Miscible with acetonitrile.

Notes
Moisture sensitive. Incompatible with strong oxidizing agents, strong acids, strong bases and strong reducing agents.
TRUSTED_SUSTAINABILITY
Density 0.918
Boiling Point 193°C
Flash Point 63°C (145°F)
Odor Unpleasant
Refractive Index 1.409
Linear Formula ((CH3)3CCO)2O
Quantity 500 g
UN Number UN3265
Beilstein 386552
Sensitivity Moisture sensitive
Solubility Information Miscible with acetonitrile.
Formula Weight 186.25
Percent Purity 99%
Chemical Name or Material Trimethylacetic anhydride
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Safety and Handling

Hazard Category H226-H314-H335
Hazard Statement GHS H Statement
H314-H318-H227
Causes severe skin burns and eye damage.
Causes serious eye damage.
Combustible liquid.
Precautionary Statement P210-P233-P235-P240-P241-P242-P243-P260-P264b-P271-P280-P301+P330+P331-P303+P361+P353-P304+P340-P305+P351+P338-P310-P363-P370+P378q-P501c
DOTInformation Hazard Class: 8; Packaging Group: II
EINECSNumber 216-263-1
TSCA Yes
Recommended Storage Ambient temperatures
SDS

RUO – Research Use Only

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