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TrkA Polyclonal Antibody, Invitrogen™
Rabbit Polyclonal Antibody
Supplier: Thermo Scientific PA590581
SDSDocumentsProduct Certifications Promotions
Positive Samples: Mouse brain, Rat brain; Cellular Location: Cell membrane, Early endosome membrane, Late endosome membrane, Single-pass type I membrane proteinTrkA (tropomyosin receptor kinase A) encodes a member of the neurotrophic tyrosine kinase receptor (NTKR) family. TrkA is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. The presence of TrkA leads to cell differentiation and may play a role in specifying sensory neuron subtypes. Mutations in TrkA have been associated with congenital insensitivity to pain, anhidrosis, self-mutilating behavior, mental retardation and cancer. Alternate transcriptional splice variants of this gene have been found, but only three have been characterized to date. Mutations in the TRKA gene have been associated with congenital insensitivity to pain, anhidrosis, self-mutilating behavior, mental retardation and cancer.
|A synthetic peptide of human NTRK1|
|Human, Mouse, Rat|
|Immunohistochemistry, Western Blot|
|PBS with 50% glycerol and 0.02% sodium azide; pH 7.3|
|P04629, P35739, Q3UFB7|
|Antigen Affinity Chromatography|
|18211, 4914, 59109|
|-20° C, Avoid Freeze/Thaw Cycles|
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