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TRMT12 Mouse anti-Human, Clone: OTI3C10, lyophilized, TrueMAB™ Non-distribution product as customer accommodation.

Mouse Monoclonal Antibody

Manufacturer:  OriGeneSupplier Diversity Partner CF809502

Catalog No. 50-166-9540


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Description

Description

Reconstitute with PBS (pH 7.3) and recommend to perform another round of desalting process using Product No. 7KMWCO

TYW2, also known as TRM12, is an enzyme that participates in the wybutosine-tRNA (Phe) biosynthesis pathway. Wybutosine (yW) is a hypermodified guanosine at the 3-prime position adjacent to the anticodon of phenylalanine tRNA that stabilizes codon-anticodon interactions during decoding on the ribosome. TYW2 is involved in a multistep enzymatic reaction that stabilizes codon-anticodon base-pairing during the ribosomal decoding process, thereby ensuring correct translation. TYW2 was found to be amplified in 7 of 8 breast cancers cell lines analyzed, and qPCR analysis of 30 breast tumors showed overexpression of TYW2 mRNA of over 2-fold in 26, suggesting that TYW2 may play a role in breast cancer.
Specifications

Specifications

TRMT12
Monoclonal
Unconjugated
TRMT12
Lyophilized
TRMT12
Full length human recombit protein of human TRMT12 produced in E.coli.
Affinity Chromatography
RUO
Antibody
Monoclonal
Human
Immunohistochemistry (Paraffin), Western Blot
OTI3C10
PBS with 8% trehalose and no preservative; pH 7.3
Q53H54
TRM12, TYW2
Mouse
IgG2a
100 μg
-20° C, Avoid Freeze/Thaw Cycles
Primary
55039
SDS
Documents
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