TRMT12 Mouse anti-Human, Clone: OTI3C10, lyophilized, TrueMAB™

Mouse Monoclonal Antibody

Supplier:  OriGene CF809502

Catalog No. 50-166-9540

Description

Reconstitute with PBS (pH 7.3) and recommend to perform another round of desalting process using Product No. 7KMWCO

TYW2, also known as TRM12, is an enzyme that participates in the wybutosine-tRNA (Phe) biosynthesis pathway. Wybutosine (yW) is a hypermodified guanosine at the 3-prime position adjacent to the anticodon of phenylalanine tRNA that stabilizes codon-anticodon interactions during decoding on the ribosome. TYW2 is involved in a multistep enzymatic reaction that stabilizes codon-anticodon base-pairing during the ribosomal decoding process, thereby ensuring correct translation. TYW2 was found to be amplified in 7 of 8 breast cancers cell lines analyzed, and qPCR analysis of 30 breast tumors showed overexpression of TYW2 mRNA of over 2-fold in 26, suggesting that TYW2 may play a role in breast cancer.

Specifications

• Antigen: TRMT12
• Classification: Monoclonal
• Conjugate: Unconjugated
• Gene: TRMT12
• Gene Alias: TRM12, TYW2
• Host Species: Mouse
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 55039
• Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
• Form: Lyophilized

• Applications: Immunohistochemistry (Paraffin), Western Blot
• Clone: OTI3C10
• Formulation: PBS with 8% trehalose and no preservative; pH 7.3
• Gene Accession No.: Q53H54
• Gene Symbols: TRMT12
• Immunogen: Full length human recombit protein of human TRMT12 produced in E.coli.
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG2a