Invitrogen™ Troponin I Polyclonal Antibody, Invitrogen™

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA5121540

Catalog No. PIPA5121540

Description

Troponin proteins associate with tropomyosin and regulate the calcium sensitivity of the myofibril contractile apparatus of striated muscles. Troponin I (TnI), along with troponin T (TnT) and troponin C (TnC), is one of 3 subunits that form the troponin complex of the thin filaments of striated muscle. TnI is the inhibitory subunit; blocking actin-myosin interactions and thereby mediating striated muscle relaxation. The TnI subfamily contains three genes: TnI-skeletal-fast-twitch, TnI-skeletal-slow-twitch, and TnI-cardiac. The TnI-fast and TnI-slow genes are expressed in fast-twitch and slow-twitch skeletal muscle fibers, respectively, while the TnI-cardiac gene is expressed exclusively in cardiac muscle tissue. This gene encodes the Troponin-I-skeletal-slow-twitch protein. This gene is expressed in cardiac and skeletal muscle during early development but is restricted to slow-twitch skeletal muscle fibers in adults. The encoded protein prevents muscle contraction by inhibiting calcium-mediated conformational changes in actin-myosin complexes.

Specifications

• Antigen: Troponin I
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: TNNI1
• Gene Alias: 2700018B22Rik; AI747285; Cardiac troponin I; cardiomyopathy, dilated 2A (autosomal recessive); CMD1FF; CMD2A; CMH7; cTNI; DKFZp451O223; RCM1; slow skeletal troponin I isoform; ssTnI; Tn1; TnI; TNN1; TNNC1; TNNI1; TNNI3; Tpn1; troponin 1, type 3; troponin I type 1 (skeletal, slow); troponin I type 3 (cardiac); troponin I, cardiac 3; troponin I, cardiac muscle; troponin I, skeletal, slow; troponin I, skeletal, slow 1; Troponin I, slow isoform; troponin I, slow skeletal; troponin I, slow skeletal muscle; Troponin I, slow-twitch isoform; troponin I1, slow skeletal type; troponin I3, cardiac type
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 21952, 21954, 7135, 7137
• Content And Storage: -20°C
• Form: Liquid

• Applications: Western Blot
• Concentration: 0.5 mg/mL
• Formulation: PBS with 50% glycerol and 0.05% ProClin 300
• Gene Accession No.: P19237, P19429, P48787, Q9WUZ5
• Gene Symbols: TNNI1, TNNI3
• Immunogen: Met1-Asp103 linked with Leu142-Gln187 (Accession P19237), with N-terminal His Tag.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse
• Product Type: Antibody
• Isotype: IgG