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TROY/TNFRSF19 Mouse anti-Human, Clone: 933202, R&D Systems™

Mouse Monoclonal Antibody

$113.85 - $319.00

Specifications

Antigen TROY/TNFRSF19
Formulation Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied as a 0.2 μm filtered solution in PBS.
Format Purified
Clone 933202
Applications CyTOF, Flow Cytometry
View More Specs

Products 2
Catalog Number Mfr. No. Quantity Price Quantity & Availability  
Catalog Number Mfr. No. Quantity Price Quantity & Availability  
MAB15481SP View Documents R&D Systems
MAB15481SP
25 ug Each for $113.85
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MAB15481100 View Documents R&D Systems
MAB15481100
100 ug Each for $319.00
Add to cart
 
Description

Description

TROY (also known as TAJ and TNFRSF19) is a 45-55kDa member of the TNF receptor superfamily of molecules (1-4). It is widely expressed in the embryo, but shows limited expression in adult. In particular, embryonic embryonic TROY is found in embryonic epithelium, neural tube, and mesenchyme, and developing neurons of the hippocampus and thalamus (5, 6). In the adult, TROY is found in the nervous system associated with dorsal root and retinal ganglia neurons, astrocytes, and microglia, and in hair follicles where it is expressed by dermal papilla matrix cells (4, 7, 8, 9). In human, TROY has also been found on melanoma cells, not normal melanocytes (10). TROY is reportedly a component of the Nogo-A receptor, taking the place of p75 in a membrane-bound LINGO-1:NgR1:TROY complex (6, 8, 9). This complex purportedly mediates axon repulsion initiated by one of five myelin-associated inhibitory factors (OMpg; CD100; Ephrin B3; Nogo-A; MAG) (6, 11). In the hair follicle, TROY binds LTa and acts with Eda to drive secondary hair follicle development (4, 12). Mature human TROY is a 394 amino acid (aa) type I transmembrane protein (1-3). It possesses a 141 aa extracellular region (aa 30-170) that contains three 40 aa TNFR cysteine motifs, and an extended 232 aa cytoplasmic domain (aa 192-423). There is one potential isoform that shows a two aa substitution for aa 416-423. The extracellular domains of human and mouse TROY share 90% aa identity.
Specifications

Specifications

TROY/TNFRSF19
Purified
CyTOF, Flow Cytometry
Mouse
Protein A or G purified from hybridoma culture supernatant
RUO
Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied as a 0.2 μm filtered solution in PBS.
933202
Unconjugated
IgG1
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 degreesC as supplied. 1 month, 2 to 8 degreesC under sterile conditions after reconstitution. 6 months, -20 to -70 degreesC under sterile conditions after reconstitution.
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