TRPM4 Mouse anti-Canine, Human, Non-human primate, Clone: OTI10H5, Invitrogen
Mouse Monoclonal Antibody
Manufacturer: Invitrogen MA524918
DescriptionCalcium-activated non selective (CAN) cation channel that mediates membrane depolarization. While it is activated by increase in intracellular Ca2+, it is impermeable to it. Mediates transport of monovalent cations (Na+, K+, Cs+, Li+), leading to depolarize the membrane. It thereby plays a central role in cadiomyocytes, neurons from entorhinal cortex, dorsal root and vomeronasal neurons, endocrine pancreas cells, kidney epithelial cells, cochlea hair cells etc. Participates in T-cell activation by modulating Ca2+ oscillations after T lymphocyte activation, which is required for NFAT-dependent IL2 production. Involved in myogenic constriction of cerebral arteries. Controls insulin secretion in pancreatic beta-cells. May also be involved in pacemaking or could cause irregular electrical activity under conditions of Ca2+ overload. Affects T-helper 1 (Th1) and T-helper 2 (Th2) cell motility and cytokine production through differential regulation of calcium signaling and NFATC1 localization. Enhances cell proliferation through up-regulation of the beta-catenin signaling pathway.
|PBS with 1% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3|
|Transient receptor potential cation channel subfamily M member 4, long transient receptor potential channel 4, hTRPM4, melastatin-4, calcium-activated|
|-20° C, Avoid Freeze/Thaw Cycles|
|484385, 54795, 719120|
|Immunohistochemistry (Paraffin), Western Blot|
|Full length human recombit protein of TRPM4 produced in HEK293T cell|
|Canine, Human, Non-human primate|
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