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TRPM4 Mouse anti-Human, Clone: OTI14C3, Invitrogen™

Mouse Monoclonal Antibody

Manufacturer:  Invitrogen MA524916

Catalog No. PIMA524916


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Description

Description

Calcium-activated non selective (CAN) cation channel that mediates membrane depolarization. While it is activated by increase in intracellular Ca2+, it is impermeable to it. Mediates transport of monovalent cations (Na+, K+, Cs+, Li+), leading to depolarize the membrane. It thereby plays a central role in cadiomyocytes, neurons from entorhinal cortex, dorsal root and vomeronasal neurons, endocrine pancreas cells, kidney epithelial cells, cochlea hair cells etc. Participates in T-cell activation by modulating Ca2+ oscillations after T lymphocyte activation, which is required for NFAT-dependent IL2 production. Involved in myogenic constriction of cerebral arteries. Controls insulin secretion in pancreatic beta-cells. May also be involved in pacemaking or could cause irregular electrical activity under conditions of Ca2+ overload. Affects T-helper 1 (Th1) and T-helper 2 (Th2) cell motility and cytokine production through differential regulation of calcium signaling and NFATC1 localization. Enhances cell proliferation through up-regulation of the beta-catenin signaling pathway.
Specifications

Specifications

TRPM4
Monoclonal
0.7 mg/mL
PBS with 1% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3
Q8TD43
Transient receptor potential cation channel subfamily M member 4, long transient receptor potential channel 4, hTRPM4, melastatin-4, calcium-activated
Mouse
IgG1
100 μL
-20° C, Avoid Freeze/Thaw Cycles
Primary
54795
Immunohistochemistry (Paraffin), Western Blot
OTI14C3
Unconjugated
TRPM4
Liquid
TRPM4
Full-length protein expressed in 293T cell transfected with human TRPM4 expression vector
Affinity Chromatography
RUO
Antibody
Monoclonal
Human
Documents
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