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TRPV1 Polyclonal Antibody, Invitrogen™

Sheep Polyclonal Antibody

Supplier:  Thermo Scientific OST00019W

Catalog No. PIOST00019W

Item Discontinued This item has been discontinued by the supplier and is no longer available. Please reach out to your sales representative.


Description

Description

Reconstitute with 100 μL of distilled water.

TRPV1 (Transient Receptor Potential Cation Channel Subfamily V Member 1) is a receptor for capsaicin, the main pungent ingredient in hot chili peppers, and elicits a sensation of burning pain by selectively activating sensory neurons. TRPV1 is a non-selective cation channel that is structurally related to members of the TRP family of ion channels such as TRPC3 and TRPC6. TRPV1 is permeable to calcium, magnesium, and monovalent cations of sodium and potassium. Structurally, TRPV1 contains 6 trans-membrane domains, a P-loop membrane domain and 3 ankyrin repeat domains. TRPV1 is also activated by increases in temperature in the noxious range, suggesting that it functions as a transducer of painful thermal stimuli in vivo. TRPV1 seems to mediate proton influx and may be involved in intracellular acidosis in nociceptive neurons. The expression of TRPV1 appears to be limited to neurons within the sensory ganglia. Four transcript variants encoding TRPV1 with variations in th 5′ UTR sequence have been described. Diseases associated with TRPV1 include Irritable Bowel Syndrome (IBS) and Bladder Disease.
TRUSTED_SUSTAINABILITY
Specifications

Specifications

TRPV1
Polyclonal
Trpv1
VR1, capsaicin receptor, vanilloid receptor 1
Sheep
100 μL
Primary
Rat
Antibody
IgG
Immunohistochemistry, Western Blot
Unconjugated
O35433
TRPV1
A synthetic peptide from rat TRPV1
RUO
83810
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Lyophilized
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