Tryptase alpha/beta 1 Antibody (TPSAB1/1961), Alexa Fluor™ 647, Novus Biologicals™

Mouse Monoclonal Antibody

Supplier:  Novus Biologicals NBP275754AF647

Catalog No. NB008880

Description

Tryptase alpha/beta 1 Monoclonal antibody specifically detects Tryptase alpha/beta 1 in Human samples. It is validated for Immunohistochemistry, Immunohistochemistry (Paraffin).

Specifications

• Antigen: Tryptase alpha/beta 1
• Classification: Monoclonal
• Conjugate: Alexa Fluor 647
• Formulation: 50mM Sodium Borate with 0.05% Sodium Azide
• Gene Alias: EC:3.4.21.59, epididymis secretory sperm binding protein, mast cell alpha II tryptase, mast cell beta I tryptase, mast cell tryptase, TPS1, TPS2, TPSB1, TPSB2, tryptase alpha II, Tryptase alpha-1, tryptase beta I, tryptase beta-1, Tryptase beta-2, Tryptase I, tryptase II, tryptase-1, tryptase-2, tryptase-I, tryptase-III
• Host Species: Mouse
• Purification Method: Protein A or G purified
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Target Species: Human
• Isotype: IgG1 κ

• Applications: Immunohistochemistry, Immunohistochemistry (Paraffin)
• Clone: TPSAB1/1961
• Dilution: Immunohistochemistry, Immunohistochemistry-Paraffin
• Gene Accession No.: Q15661
• Gene Symbols: TPSAB1
• Immunogen: Recombinant human Tryptase alpha/TPS1 protein fragment (around aa 115-233) (Exact sequence is proprietary) (Uniprot: Q15661)
• Quantity: 0.1 mL
• Research Discipline: Immunology, metabolism
• Test Specificity: This antibody reacts with mast cells distributed in skin, synovium, lung, and heart. This antibody does not bind with any other cell type. Human mast cell tryptase is considered to be an important marker of mast cell activation and is an important mediator of inflammation. Mastocytosis is a term collectively used for a group of disorders in which there is abnormal accumulation of mast cells in one or multiple organs. Anti-tryptase, combined with anti-CD2, anti-CD25, and anti-CD117, can be useful in identifying reactive mast cell hyperplasia, myelogenous neoplasms, mast cell leukemia, and mastocytosis. Due to sequence identity this antibody will likely cross react with tryptase beta 2.
• Content And Storage: Store at 4°C in the dark.