Tryptase alpha/TPS1, Mouse anti-Human, Janelia Fluor 549, Clone: TPSAB1/1961, Novus Biologicals™

Mouse Monoclonal Antibody

Manufacturer:  Novus Biologicals NBP275754JF549

Catalog No. NB008891

Description

Tryptase alpha/TPS1 Monoclonal antibody specifically detects Tryptase alpha/TPS1 in Human samples. It is validated for Immunohistochemistry, Immunohistochemistry (Paraffin).

Specifications

• Antigen: Tryptase alpha/TPS1
• Clone: TPSAB1/1961
• Dilution: Immunohistochemistry, Immunohistochemistry-Paraffin
• Formulation: 50mM Sodium Borate with 0.05% Sodium Azide
• Gene Symbols: TPSAB1
• Immunogen: Recombinant human Tryptase protein fragment (around aa 115-233) (Exact sequence is proprietary)
• Monoclonal or Polyclonal: Monoclonal
• Purification Method: Protein A or G purified
• Regulatory Status: RUO
• Target Species: Human

• Applications: Immunohistochemistry,Immunohistochemistry (Paraffin)
• Conjugate: Janelia Fluor 549
• Format: Purified,Conjugated
• Gene Alias: TPS1, TPS2, TPSAB1, TPSB1, tryptase alpha/beta 1
• Host Species: Mouse
• Isotype: IgG1 Kappa
• Primary or Secondary: Primary
• Quantity: 0.1 mL
• Storage Requirements: Store at 4°C in the dark.
• Test Specificity: Tryptases comprise a family of trypsin-like serine proteases (peptidase family S1). Tryptases are stored in mast cell secretory granules and basophils. Mast cells are connective tissue cells derived from blood-forming tissues that line arterial walls and secrete substances, which mediate inflammatory and immune responses. Tryptases are released into the extracellular environment and are resistant to all known endogenous proteinase inhibitors. This antibody reacts with mast cells distributed in skin, synovium, lung, and heart. This antibody does not bind with any other cell type. Human mast cell tryptase is considered to be an important marker of mast cell activation and is an important mediator of inflammation. Mastocytosis is a term collectively used for a group of disorders in which there is abnormal accumulation of mast cells in one or multiple organs. Anti-tryptase, combined with anti-CD2, anti-CD25, and anti-CD117, can be useful in identifying reactive mast cell hyperplasia, myelogenous neoplasms, mast cell leukemia, and mastocytosis.