TSN Mouse anti-Human, Clone: OTI1B5, Invitrogen
Mouse Monoclonal Antibody
Manufacturer: Invitrogen MA527091
DescriptionTranslin is a DNA-binding protein which specifically recognizes conserved target sequences at the breakpoint junction of chromosomal translocations. Translin polypeptides form a multimeric structure that is responsible for its DNA-binding activity. Recombination-associated motifs and translin-binding sites are present at recombination hotspots and may serve as indicators of breakpoints in genes which are fused by translocations. These binding activities may play a crucial role in chromosomal translocation in lymphoid neoplasms. Recent evidence suggests that in combination with a binding partner Trax, Translin binds RNA and mediates trafficking in neurons.
|PBS with 1% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3|
|BCLF-1, RCHF1, REHF-1, TBRBP, TRSLN; recombination hotspot associated factor; recombination hotspot-binding protein|
|-20° C, Avoid Freeze/Thaw Cycles|
|Immunohistochemistry (Paraffin), Western Blot|
|Human recombit protein fragment corresponding to amino acids 1-51 of TSN produced in E.coli|
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