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TSPAN12 Mouse anti-Human, Alexa Fluor 647, Clone: 921938, R&D Systems™

Mouse Monoclonal Antibody

Manufacturer:  R&D Systems FAB8910R025

Catalog No. FAB8910R025


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Description

Description

TSPAN12 is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. They mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. TSPAN12 plays a central role in retinal vascularization by regulating norrin signal transduction. TSPAN12 acts in concert with norrin to promote FZD4 multimerization and subsequent activation of FZD4, leading to promote accumulation of beta-catenin and stimulate LEF/TCF-mediated transcriptional programs. Defects in TSPAN12 are the cause of vitreoretinopathy exudative type 5, a disorder of the retinal vasculature characterized by an abrupt cessation of growth of peripheral capillaries, leading to an avascular peripheral retina.
Specifications

Specifications

TSPAN12
921938
Flow Cytometry 5 uL/10^6 cells
O95859
EVR5, Leukemia-associated protein with a CXXC domain, methylcytosine dioxygenase TET1, NET2, NET-2, ten-eleven translocation-1, tetraspanin-12, TM4SF12
Mouse
IgG2b
25 Tests
Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 degreesC as supplied.
Monoclonal
Stains human TSPAN12 transfectants but not irrelevant transfectants in flow cytometry.
Flow Cytometry
Alexa Fluor 647
Supplied in a saline solution containing BSA and Sodium Azide. with Sodium Azide
Purified
TSPAN12
NS0 mouse myeloma cell line transfected with human TSPAN12 Met1-Leu305 Accession # O95859
Protein A or G purified from hybridoma culture supernatant
RUO
Primary
23554
Human
SDS
Documents
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