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TTBK2 Rabbit anti-Human, Mouse, Rat, Polyclonal, Proteintech Non-distribution product as customer accommodation.

Rabbit Polyclonal Antibody

Manufacturer:  Proteintech Group IncSupplier Diversity Partner 150721AP

Catalog No. 50-172-9952


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Description

Description

15072-1-AP has a cross reaction with TTBK1.

Tau tubulin kinase (TTBK2) is a serine/threonine kinase whose substrates are thought to include the tau and tubulin proteins. Mutations in the TTBK2 gene cause spinocerebellar ataxia type 11 (SCA11), a neurodegenerative disease characterized by progressive ataxia and atrophy of the cerebellum and brainstem. Recent studies have shown that increased levels of TTBK2 expression in kidney carcinoma and melanoma cell lines increases resistance to the chemotherapeutic agent Sunitinib, and that reduction of TTBK2 though the use of siRNA sensitized these cell lines to the effects of Sunitib, suggesting that TTBK2 can be used as a resistance marker as well a potential target to overcome resistance.
Specifications

Specifications

TTBK2
0.37 mg/mL
PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
Q3UVR3, Q6IQ55
KIAA0847, SCA11, tau tubulin kinase 2, TTBK, TTBK2
Rabbit
IgG
150 μL
-20°C
Primary
140810, 146057, 311349
Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot
Unconjugated
TTBK2
Liquid
TTBK2
TTBK2 Fusion Protein Ag7108
Antigen Affinity Chromatography
RUO
Antibody
Polyclonal
Human, Mouse, Rat
Documents
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