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TTI1 Rabbit anti-Human, Mouse, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA550852

Catalog No. PA550852


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Description

Description

The antibody detects endogenous levels of total TTI1 protein.

Regulator of the DNA damage response (DDR). Part of the TTT complex that is required to stabilize protein levels of the phosphatidylinositol 3-kinase-related protein kinase (PIKK) family proteins. The TTT complex is involved in the cellular resistance to DNA damage stresses, like ionizing radiation (IR), ultraviolet (UV) and mitomycin C (MMC). Together with the TTT complex and HSP90 may participate in the proper folding of newly synthesized PIKKs. Promotes assembly, stabilizes and maintains the activity of mTORC1 and mTORC2 complexes, which regulate cell growth and survival in response to nutrient and hormonal signals.
Specifications

Specifications

TTI1
Polyclonal
Unconjugated
TTI1
Liquid
TTI1
Synthetic peptide corresponding to residues near the N terminal of human TELO2 interacting protein 1
Antigen affinity chromatography
RUO
Antibody
Polyclonal
Human, Mouse
Immunohistochemistry (Paraffin)
2.7 mg/mL
PBS with 40% glycerol and 0.05% sodium azide; pH 7.4
O43156, Q91V83
KIAA0406, SMG10
Rabbit
IgG
100 μL
-20°C
Primary
75425, 9675
Documents
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