S1P3 receptor antagonist (Ki = 110nM); inhibits S1P-induced Ca2+ release in HUVEC cells. Suppresses FTY-720-induced S1P3 receptor-mediated bradycardia in vivo. Also inhibits S1P-induced breast cancer stem cell expansion in vitro. Orally bioavailable.
Chemical Name: N-(4-Chlorophenyl)-3,3-dimethyl-2-oxobutanimidic 2-(4-chlorophenyl) hydrazide
CAS Number: 934369-14-9
Solubility: Soluble to 100mM in DMSO and to 100mM in ethanol
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