TYMS Mouse anti-Human, Clone: OTI1C4, lyophilized, TrueMAB
Mouse Monoclonal Antibody
Manufacturer: OriGene CF801811
Reconstitute with PBS (pH 7.3) and recommend to perform another round of desalting process using Product No. 7KMWCOThymidylate Synthase (TS) (EC 126.96.36.199) converts deoxyuridine monophosphate (dUMP) to deoxythymidine monophosphate (dTMP), which is essential for DNA biosynthesis. TS is a critical target for the fluoropyrimidines, an important group of antineoplastic drugs that are widely used in the treatment of solid tumors. Both 5-FU and fluorodeoxyuridine are converted in tumor cells to FdUMP which inactivates TS by formation of a ternary covalent complex in the presence of the folate cofactor 5,10-methylenetetrahydrofolate. Expression of TS protein is associated with response to 5-fluorouracil (5-FU) in human colorectal, gastric, head and neck, and breast carcinomas.
|Full length human recombit protein of human TYMS produced in E.coli.|
|PBS with 8% trehalose and no preservative; pH 7.3|
|HST422, TMS, TS|
|-20° C, Avoid Freeze/Thaw Cycles|
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