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TYMS Mouse anti-Human, Clone: UMAB227, liquid, UltraMAB™
Mouse Monoclonal Antibody
Supplier: OriGene UM800119
SDSDocumentsProduct Certifications Promotions
DescriptionThymidylate Synthase (TS) (EC 184.108.40.206) converts deoxyuridine monophosphate (dUMP) to deoxythymidine monophosphate (dTMP), which is essential for DNA biosynthesis. TS is a critical target for the fluoropyrimidines, an important group of antineoplastic drugs that are widely used in the treatment of solid tumors. Both 5-FU and fluorodeoxyuridine are converted in tumor cells to FdUMP which inactivates TS by formation of a ternary covalent complex in the presence of the folate cofactor 5,10-methylenetetrahydrofolate. Expression of TS protein is associated with response to 5-fluorouracil (5-FU) in human colorectal, gastric, head and neck, and breast carcinomas.
|HST422, TMS, TS|
|-20° C, Avoid Freeze/Thaw Cycles|
|Immunohistochemistry (Paraffin), Western Blot|
|PBS with 1% BSA, 50% glycerol and 0.02% sodium azide|
|Full length human recombit protein of human TYMS (TS) produced in E.coli.|
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