Tyrosinase Mouse anti-Human, Janelia Fluor™ 646, Clone: T311, Novus Biologicals™

Mouse Monoclonal Antibody

Manufacturer:  Novus Biologicals NBP233160JF646

Catalog No. N233160J646

Description

Tyrosinase Monoclonal antibody specifically detects Tyrosinase in Human samples. It is validated for ELISA.

Specifications

• Antigen: Tyrosinase
• Clone: T311
• Dilution: Flow Cytometry, Immunohistochemistry, Immunocytochemistry/Immunofluorescence, Immunohistochemistry-Paraffin
• Formulation: 50mM Sodium Borate with 0.05% Sodium Azide
• Gene ID (Entrez): 7299.0
• Host Species: Mouse
• Isotype: IgG2a Kappa
• Primary or Secondary: Primary
• Quantity: 0.1 mL
• Storage Requirements: Store at 4°C in the dark.
• Test Specificity: Recognizes a cluster of proteins between 70-80kDa, identified as tyrosinase. Occasionally a minor band at 55kDa is also detected. This MAb shows no cross-reaction with MAGE-1 and tyrosinase-related protein 1, TRP-1/gp75. Tyrosinase is a copper-containing metalloglycoprotein that catalyzes several steps in the melanin pigment biosynthetic pathway; the hydroxylation of tyrosine to L-3,4-dihydroxy-phenylalanine (dopa), and the subsequent oxidation of dopa to dopaquinone. Mutations of the tyrosinase gene occur in various forms of albinism. Tyrosinase is one of the targets for cytotoxic T-cell recognition in melanoma patients. Staining of melanomas with this MAb shows tyrosinase in melanotic as well as amelanotic variants. This MAb is a useful marker for melanocytes and melanomas.

• Applications: Flow Cytometry,Immunohistochemistry,Immunocytochemistry,Immunofluorescence,Immunohistochemistry (Paraffin)
• Conjugate: Janelia Fluor 646
• Format: Purified,Conjugated
• Gene Alias: CMM8, EC 1.14.18.1, LB24-AB, Monophenol monooxygenase, OCA1A, OCAIA, SHEP3, SK29-AB, Tumor rejection antigen AB, tyrosinase, tyrosinase (oculocutaneous albinism IA)
• Gene Symbols: TYR
• Immunogen: Recombinant tyrosinase protein
• Monoclonal or Polyclonal: Monoclonal
• Purification Method: Protein G purified
• Research Discipline: Lipid and Metabolism
• Target Species: Human