Tyrosinase Mouse anti-Human, Alexa Fluor 532, Clone: T311, Novus Biologicals
Mouse Monoclonal Antibody
Manufacturer: Novus Biologicals NBP233160AF532
DescriptionTyrosinase Monoclonal antibody specifically detects Tyrosinase in Human samples. It is validated for ELISA.
|Flow Cytometry, Immunohistochemistry, Immunocytochemistry/Immunofluorescence, Immunohistochemistry-Paraffin|
|Recombinant tyrosinase protein|
|Protein G purified|
|Lipid and Metabolism|
|Flow Cytometry, Immunocytochemistry, Immunofluorescence, Immunohistochemistry, Immunohistochemistry (Paraffin)|
|Alexa Fluor™ 532|
|50 mM sodium borate with 0.05% sodium azide|
|CMM8, EC 184.108.40.206, LB24-AB, Monophenol monooxygenase, OCA1A, OCAIA, SHEP3, SK29-AB, Tumor rejection antigen AB, tyrosinase, tyrosinase (oculocutaneous albinism IA)|
|Store at 4°C in the dark.|
|Recognizes a cluster of proteins between 70-80kDa, identified as tyrosinase. Occasionally a minor band at 55kDa is also detected. This MAb shows no cross-reaction with MAGE-1 and tyrosinase-related protein 1, TRP-1/gp75. Tyrosinase is a copper-containing metalloglycoprotein that catalyzes several steps in the melanin pigment biosynthetic pathway; the hydroxylation of tyrosine to L-3,4-dihydroxy-phenylalanine (dopa), and the subsequent oxidation of dopa to dopaquinone. Mutations of the tyrosinase gene occur in various forms of albinism. Tyrosinase is one of the targets for cytotoxic T-cell recognition in melanoma patients. Staining of melanomas with this MAb shows tyrosinase in melanotic as well as amelanotic variants. This MAb is a useful marker for melanocytes and melanomas.|
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