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Tyrosinase Mouse anti-Human, Alexa Fluor™ 594, Clone: T311, Novus Biologicals™

Mouse Monoclonal Antibody

Manufacturer:  Novus BiologicalsSupplier Diversity Partner NBP233160AF594

Catalog No. NP233160A94


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Description

Description

Tyrosinase Monoclonal antibody specifically detects Tyrosinase in Human samples. It is validated for ELISA.
Specifications

Specifications

Tyrosinase
T311
ELISA
Conjugated, Purified
TYR
Recombinant tyrosinase protein
Protein G purified
Lipid and Metabolism
Primary
7299.0
Human
ELISA
Alexa Fluor™ 594
50 mM sodium borate with 0.05% sodium azide
CMM8, EC 1.14.18.1, LB24-AB, Monophenol monooxygenase, OCA1A, OCAIA, SHEP3, SK29-AB, Tumor rejection antigen AB, tyrosinase, tyrosinase (oculocutaneous albinism IA)
Mouse
IgG2a Kappa
0.1 mL
Store at 4°C in the dark.
Monoclonal
Recognizes a cluster of proteins between 70-80kDa, identified as tyrosinase. Occasionally a minor band at 55kDa is also detected. This MAb shows no cross-reaction with MAGE-1 and tyrosinase-related protein 1, TRP-1/gp75. Tyrosinase is a copper-containing metalloglycoprotein that catalyzes several steps in the melanin pigment biosynthetic pathway; the hydroxylation of tyrosine to L-3,4-dihydroxy-phenylalanine (dopa), and the subsequent oxidation of dopa to dopaquinone. Mutations of the tyrosinase gene occur in various forms of albinism. Tyrosinase is one of the targets for cytotoxic T-cell recognition in melanoma patients. Staining of melanomas with this MAb shows tyrosinase in melanotic as well as amelanotic variants. This MAb is a useful marker for melanocytes and melanomas.
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