TRMT12 Mouse anti-Human, Clone: OTI3C10, Invitrogen
Mouse Monoclonal Antibody
Manufacturer: Invitrogen MA527169
DescriptionTYW2, also known as TRM12, is an enzyme that participates in the wybutosine-tRNA (Phe) biosynthesis pathway. Wybutosine (yW) is a hypermodified guanosine at the 3-prime position adjacent to the anticodon of phenylalanine tRNA that stabilizes codon-anticodon interactions during decoding on the ribosome. TYW2 is involved in a multistep enzymatic reaction that stabilizes codon-anticodon base-pairing during the ribosomal decoding process, thereby ensuring correct translation. TYW2 was found to be amplified in 7 of 8 breast cancers cell lines analyzed, and qPCR analysis of 30 breast tumors showed overexpression of TYW2 mRNA of over 2-fold in 26, suggesting that TYW2 may play a role in breast cancer.
|PBS with 1% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3|
|TRM12, TYW2; alpha-amino-alpha-carboxypropyl transferase TYW2; homolog of yeast tRNA methyltransferase; tRNA methyltranferase 12 homolog; tRNA wybutosine-synthesizing protein 2 homolog; tRNA-yW synthesizing protein 2; tRNA-yW-synthesizing protein 2|
|-20° C, Avoid Freeze/Thaw Cycles|
|Immunohistochemistry (Paraffin), Western Blot|
|Full length human recombit protein of TRMT12 produced in E.coli|
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