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UBE2E3 Mouse anti-Canine, Human, Mouse, Non-human primate, Rat, Clone: OTI7E8, Invitrogen™

Mouse Monoclonal Antibody

Manufacturer:  Invitrogen MA526364

Catalog No. PIMA526364

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The ubiquitin (Ub) pathway involves three sequential enzymatic steps that facilitate the conjugation of Ub and Ub-like molecules to specific protein substrates.The first step requires the ATP-dependent activation of the Ub C-terminusand the assembly of multi-Ub chains by the Ub-activating enzyme known as the E1 component. The Ub chain is then conjugated to the Ub-conjugating enzyme (E2) to generate an intermediate Ub-E2 complex. The Ub-ligase (E3) then catalyzes the transfer of Ub from E2 to the appropriate protein substrate. A wide range of enzymes facilitate in the proteolytic Ub pathway including UBE2E3, also designated UBCH9, which catalyzes the covalent attachment of ubiquitin to other proteins and is involved in the regulation of transepithelial sodium transport in renal cells. UBE2E3 may also be involved in cell growth arrest. The UBE2E3 protein shuttles between the cytoplasm and nucleus in a IPO11-dependent manner. It is ubiquitously expressed at low levels and is highly expressed in skeletal muscle.


1 mg/mL
PBS with 1% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3
Q969T4, P52483
UBCH9, UbcM2, ubiquitin carrier protein E3, ubiquitin-conjugating enzyme E2 E3, ubiquitin-conjugating enzyme E2-23 kDa, ubiquitin-conjugating enzyme E2E 3 (UBC4/5 homolog, yeast), ubiquitin-conjugating enzyme E2E 3 (homologous to yeast UBC4/5), ubiquitin-protein ligase E3
100 μL
-20° C, Avoid Freeze/Thaw Cycles
10477, 22193, 295686, 612823, 704530
Flow Cytometry, Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot
Full length human recombit protein of UBE2E3 produced in E.coli
Affinity Chromatography
Canine, Human, Mouse, Non-human primate, Rat
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