UBE2O Rabbit anti-Human, Mouse, Polyclonal, Proteintech
Rabbit Polyclonal Antibody
Manufacturer: Proteintech Group Inc 158121AP
DescriptionE2/E3 hybrid ubiquitin-protein ligase that displays both E2 and E3 ligase activities and mediates monoubiquitination of target proteins. Negatively regulates TRAF6-mediated NF-kappa-B activation independently of its E2 activity. Acts as a positive regulator of BMP7 signaling by mediating monoubiquitination of SMAD6, thereby regulating adipogenesis. Mediates monoubiquitination at different sites of the nuclear localization signal (NLS) of BAP1, leading to cytoplasmic retention of BAP1. Also able to monoubiquitinate the NLS of other chromatin-associated proteins, such as INO80 and CXXC1, affecting their subcellular location. Acts as a regulator of retrograde transport by assisting the TRIM27:MAGEL2 E3 ubiquitin ligase complex to mediate ft.Lys-63 ft.-linked ubiquitination of WASHC1, leading to promote endosomal F-actin assembly.
|PBS with 50% glycerol and 0.02% sodium azide; pH 7.3|
|E2-230K, KIAA1734, UBE2O, Ubiquitin carrier protein O, Ubiquitin protein ligase O|
|Immunohistochemistry (Paraffin), Western Blot|
|UBE2O Fusion Protein Ag8580|
|Antigen Affinity Chromatography|
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