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UBE2O Rabbit anti-Human, Mouse, Polyclonal, Proteintech Non-distribution product as customer accommodation.

Rabbit Polyclonal Antibody

Manufacturer:  Proteintech Group IncSupplier Diversity Partner 158121AP

Catalog No. 50-173-0500


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Description

Description

E2/E3 hybrid ubiquitin-protein ligase that displays both E2 and E3 ligase activities and mediates monoubiquitination of target proteins. Negatively regulates TRAF6-mediated NF-kappa-B activation independently of its E2 activity. Acts as a positive regulator of BMP7 signaling by mediating monoubiquitination of SMAD6, thereby regulating adipogenesis. Mediates monoubiquitination at different sites of the nuclear localization signal (NLS) of BAP1, leading to cytoplasmic retention of BAP1. Also able to monoubiquitinate the NLS of other chromatin-associated proteins, such as INO80 and CXXC1, affecting their subcellular location. Acts as a regulator of retrograde transport by assisting the TRIM27:MAGEL2 E3 ubiquitin ligase complex to mediate  ft.Lys-63 ft.-linked ubiquitination of WASHC1, leading to promote endosomal F-actin assembly.
Specifications

Specifications

UBE2O
0.27 mg/mL
PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
Q6ZPJ3, Q9C0C9
E2-230K, KIAA1734, UBE2O, Ubiquitin carrier protein O, Ubiquitin protein ligase O
Rabbit
IgG
150 μL
-20°C
Primary
217342, 63893
Immunohistochemistry (Paraffin), Western Blot
Unconjugated
UBE2O
Liquid
UBE2O
UBE2O Fusion Protein Ag8580
Antigen Affinity Chromatography
RUO
Antibody
Polyclonal
Human, Mouse
Documents
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