Invitrogen™ Ubiquilin 4 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA520781

Catalog No. PIPA520781

Description

A suggested positive control is NIH-3T3 cell lysate. PA5-20781 can be used with blocking peptide PEP-0895.

The ubiquitin-proteosome pathway of protein degradation is one of the mechanisms that ensure the proper level of cellular proteins. The ubiquitin-like (UbL) and ubiquitin-associated (UBA) domain containing protein family is thought to be involved in proteosomal degradation. One such protein is CIP75, also known as ubiquilin-4, interacts with a number of proteins such as Ataxin-1 and Connexin-43, resulting in an increased rate of turnover of these proteins. Overexpression CIP75 led to a significant reduction of Connexin-43 half-life, with the opposite being observed in siRNA knockdown experiments. CIP75 contains an N-terminal UbL domain which is thought to interact with proteins of the 26S proteosome complex and a C-terminal UBA domain which appears to mediate its interaction with Connexin-75. At least three isoforms of CIP75 are known to exist.

Specifications

• Antigen: Ubiquilin 4
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: UBQLN4
• Gene Alias: A1u; A1Up; AI663987; Ataxin-1 interacting ubiquitin-like protein; ataxin-1 ubiquitin-like interacting protein; ataxin-1 ubiquitin-like-interacting protein A1U; C1orf6; CIP75; Connexin43-interacting protein of 75 kDa; RGD1308273; RP11-336K24.8; UBIN; ubiquilin 4; ubiquilin-4; UBQLN4
• Host Species: Rabbit
• Purification Method: Antigen Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 310633, 56893, 94232
• Content And Storage: Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
• Form: Liquid

• Applications: Immunohistochemistry, Western Blot
• Concentration: 1 mg/mL
• Formulation: PBS with 0.02% sodium azide
• Gene Accession No.: Q99NB8, Q9NRR5
• Gene Symbols: UBQLN4
• Immunogen: An 18 amino acid peptide near the amino terminus of human CIP75.
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG