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Ubiquitin Mouse anti-All, Biotin, Clone: eBioP4D1 (P4D1), eBioscience™ Non-distribution product as customer accommodation.

Mouse Monoclonal Antibody

$98.50 - $225.00

Specifications

Antigen Ubiquitin
Clone eBioP4D1 (P4D1)
Target Species All
Conjugate Biotin
Isotype IgG1
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Products 2
Catalog Number Mfr. No. Quantity Price Quantity & Availability  
Catalog Number Mfr. No. Quantity Price Quantity & Availability  
50-121-29 Non-distribution product as customer accommodation.
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Invitrogen
13607880
25 μg Each for $98.50
Add to cart
 
50-121-30 Non-distribution product as customer accommodation.
View Documents
Invitrogen
13607882
100 μg Each for $225.00
Add to cart
 
Description

Description

Description: The monoclonal antibody eBioP4D1 (p4D1) recognizes ubiquitin, a small 8Ka protein. Ubiquitin units are linked to proteins via a ubiquitination process, thereby signaling the protein for degradation by the 26S proteosome. The process of ubiquitination plays a role in differentiation, cell cycle progression, apoptosis and disease progression. For example, neuronal inclusions called Lewis bodies from Parkinson patients are rich in ubiquitin. Applications Reported: This eBioP4D1 (P4D1) antibody has been reported for use in immunoblotting (WB). Applications Tested: This eBioP4D1 (P4D1) antibody has been tested by immunoblotting of treated cell lines. This can be used at less than or equal to 0.5 µg/mL. It is recommended that the antibody be carefully titrated for optimal performance in the assay of interest. Filtration: 0.2 µm post-manufacturing filtered.

Ubiquitin is a conserved 76 amino acid polypeptide and can affect proteasomal degradation of the protein it is bound to, or mediate interactions with other proteins related to post-translational modifications. The degradation of cellular regulatory proteins by the Uubiquitin pathway is important as it controls the cellular growth and proliferation. Ubiquitin-dependent proteolysis occurs after a covalent attachment of the peptide to a lysine residue of a protein, which involves three enzymatic reactions: E1, E2 and E3. The first reaction involves ubiquitin-activating enzyme. The third reaction uses enzyme ubiquitin ligase (E3) to transfer the activated ubiquitin from E2 to a lysine residue on a protein, or directly transfers the ubiquitin from E2 to the substrate.
Specifications

Specifications

Ubiquitin
All
IgG1
Monoclonal
Liquid
Antibody
4° C, store in dark, DO NOT FREEZE!
eBioP4D1 (P4D1)
Biotin
Western Blot
Primary
Monoclonal
PBS with 0.1% gelatin and 0.09% sodium azide; pH 7.2
RUO

For Research Use Only.

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