Tocris™ UBP 310

GLUK5 antagonist

Manufacturer: Tocris™ 3621/10

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Catalog No. 36-211-0R

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For Research Use Only


    Product Type UBP 310
    Inhibitors UBP 310
    Purity >98
    Molecular Weight 353.35
    Quantity 10mg

    GLUK5 kainate receptor antagonist (IC50 = 130nM); also blocks recombinant homomeric GLUK7 receptors. Displays 12,700-fold selectivity for GLUK5 over GLUK6. Exhibits no activity at mGlu group I or NMDA receptors at concentrations of up to 10µM. Apparent KD value is 18 ± 4nM for depression of kainate responses on the dorsal root.

    • Chemical Name: (S)-1-(2-Amino-2-carboxyethyl)-3-(2-carboxy-thiophene-3-yl-methyl)-5-methylpyrimidine-2,4-dione
    • Formula: C14H15N3O6S
    • CAS Number: 902464-46-4
    • Solubility: Soluble to 100mM in DMSO
    • Purity: >98

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