Invitrogen™ UBR1 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA542370

Catalog No. PIPA542370

Description

Peptide sequence: YKQLQKEYIS DDHDRSISIT ALSVQMFTVP TLARHLIEEQ NVISVITETL Sequence homology: Cow: 93%; Dog: 100%; Guinea Pig: 100%; Horse: 93%; Human: 100%; Mouse: 93%; Rabbit: 100%; Rat: 100%; Yeast: 82%.

ELK1 is a component of the ternary complex that binds the serum response element (SRE) and mediates gene activity in response to serum and growth factors. ELK1 is phosphorylated by MAP kinase pathways at a cluster of S/T motifs at its C-terminus. Phosphorylation at these sites, particularly Ser383, is critical for transcriptional activation by ELK1. ELK1 appears to be a direct target of activated MAP kinase. Biochemical studies indicate that ELK1 is a good substrate for MAP kinase, the kinetics of ELK1 phosphorylation and activation correlate with MAP kinase activity, and interfering mutants of MAP kinase block ELK1 activation in vivo. ELK1 is a nuclear target for the ras-raf-MAPK signaling cascade. Alternatively spliced transcript variants encoding the same protein have been found for ELK1.

Specifications

• Antigen: UBR1
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: UBR1
• Gene Alias: AI504731; E3 alpha; E3 ubiquitin-protein ligase UBR1; E3a ligase; JBS; LOW QUALITY PROTEIN: E3 ubiquitin-protein ligase UBR1; MGC142065; MGC142067; N-recognin-1; RGD1562326; RING-type E3 ubiquitin transferase UBR1; ubiquitin ligase E3 alpha-I; ubiquitin protein ligase E3 component n-recognin 1; ubiquitin-protein ligase e3 componen n-recognin; ubiquitin-protein ligase E3-alpha; ubiquitin-protein ligase E3-alpha-1; Ubiquitin-protein ligase E3-alpha-I; Ubr1
• Host Species: Rabbit
• Purification Method: Affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 197131
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: Western Blot
• Concentration: 0.5 mg/mL
• Formulation: PBS with 2% sucrose and 0.09% sodium azide
• Gene Accession No.: Q8IWV7
• Gene Symbols: UBR1
• Immunogen: Synthetic peptide directed towards the N-terminal of human UBR1 (aa 396-445).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov