Tocris UC 112
IAP and XIAP inhibitor; antitumor
Manufacturer: Tocris 5251/50
DescriptionIAP inhibitor (IC50 values from 0.7 - 3.4µM); inhibits cell growth in multiple cancer cell lines and in a melanoma xenograft model in vivo. Also suppresses X-linked inhibitor of apoptosis protein (XIAP) and survivin levels. Inhibits the growth of P-glycoproteins and activates caspase-3/7 and caspase-9.
- Chemical Name: 5-[(Phenylmethoxy)methyl]-7-(1-pyrrolidinylmethyl)-8-quinolinol
- Formula: C22H24N2O2
- CAS Number: 383392-66-3
- Solubility: Soluble to 100mM in DMSO
- Purity: >98
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