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Tocris™ UC 112

IAP and XIAP inhibitor; antitumor

Manufacturer:  Tocris™ 5251/50

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Catalog No. 52-515-0

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For Research Use Only



IAP inhibitor (IC50 values from 0.7 - 3.4µM); inhibits cell growth in multiple cancer cell lines and in a melanoma xenograft model in vivo. Also suppresses X-linked inhibitor of apoptosis protein (XIAP) and survivin levels. Inhibits the growth of P-glycoproteins and activates caspase-3/7 and caspase-9.
  • Chemical Name: 5-[(Phenylmethoxy)methyl]-7-(1-pyrrolidinylmethyl)-8-quinolinol
  • Formula: C22H24N2O2
  • CAS Number: 383392-66-3
  • Solubility: Soluble to 100mM in DMSO
  • Purity: >98
Description & Specifications


UC 112
UC 112
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