UCP3 Mouse anti-Human, Clone:6B8C6, Abnova™
Mouse monoclonal antibody raised against recombinant human UCP3.
Manufacturer: Abnova Corporation MAB17211
DescriptionMitochondrial uncoupling proteins (UCP) are members of the larger family of mitochondrial anion carrier proteins (MACP). UCPs separate oxidative phosphorylation from ATP synthesis with energy dissipated as heat, also referred to as the mitochondrial proton leak. UCPs facilitate the transfer of anions from the inner to the outer mitochondrial membrane and the return transfer of protons from the outer to the inner mitochondrial membrane. They also reduce the mitochondrial membrane potential in mammalian cells. The different UCPs have tissue-specific expression; this gene is primarily expressed in skeletal muscle. This gene′s protein product is postulated to protect mitochondria against lipid-induced oxidative stress. Expression levels of this gene increase when fatty acid supplies to mitochondria exceed their oxidation capacity and the protein enables the export of fatty acids from mitochondria. UCPs contain the three solcar protein domains typically found in MACPs. Two splice variants have been found for this gene
|uncoupling protein 3 (mitochondrial, proton carrier)|
|In PBS (0.05% sodium azide)|
|Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.
|ELISA, Immunocytochemistry, Western Blot|
Western Blot (1:500-1:2000)
The optimal working dilution should be determined by the end user.
|Recombinant protein corresponding to amino acid 1-113 and 217-312 of human UCP3 from E. coli.|
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