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UFD1L Mouse anti-Human, Clone: OTI4C7, Invitrogen™

Mouse Monoclonal Antibody

Manufacturer:  Invitrogen MA526659

Catalog No. PIMA526659


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Description

Description

Ubiquitin-mediated proteolysis requires the transfer of ubiquitin (Ub) to lysine groups on selected cellular proteins, which then potentiates the proteolytic degradation of these protein conjugates by the 26S proteasome. Ub-fusions are cleaved by Ub-specific processing proteases (UBps) or alternatively by the Ub-fusion degradation (UFD) pathway. The UBP pathway targets the C-terminal glycine residue on Ub that is involved in the formation of Ub-conjugates, while UFD proteins preferentially cleave Ub-conjugated proteins that contain an amino acid substitution at this glycine residue. The UFD1 protein was originally characterized in the yeast S. cerevisiae and subsequently, the human homolog UFD1 or UFD1L was identified. In vitro, UFD1 attenuates the degradation of Ub-fusions, which have a proline or valine residue substituted at the Gly76 moiety, by the selective multiubiquitination of the Ub chain of the Ub-conjugate. Mutations within the UFD1 gene are implicated in the development of CATCH22 syndrome, which is characterized by cardiac defects, cleft palate and hypocalcemia, suggesting that this proteolytic pathway may be involved in the progression of these developmental defects.
Specifications

Specifications

UFD1L
Monoclonal
1 mg/mL
PBS with 1% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3
Q92890
Ubiquitin fusion degradation protein 1 homolog; UB fusion protein 1; UFD1L
Mouse
IgG1
100 μL
-20° C, Avoid Freeze/Thaw Cycles
Primary
7353
Immunohistochemistry (Paraffin), Western Blot
OTI4C7
Unconjugated
UFD1
Liquid
UFD1
Full length human recombit protein of UFD1L produced in E.coli
Affinity Chromatography
RUO
Antibody
Monoclonal
Human
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