Tocris™ UNC 0642

Potent and selective G9a and GLP inhibitor

Manufacturer: Tocris™ 5132/50

 View more versions of this product

Catalog No. 51-325-0

  Check Availability
Add to Cart


For Research Use Only


    Inhibitors UNC 0642
    Purity >99
    Molecular Weight 546.7
    Quantity 50mg
    Product Type UNC 0642

    Potent and selective G9a and GLP histone lysine methyltransferase inhibitor (IC50 < 2.5nM). Exhibits >2,000-fold selectivity for G9a and GLP over PRC2-EZH2 and >20,000-fold selectivity over other methyltransferases. Reduces H3K9 dimethylation levels in MDA-MB-231 cells (IC50 = 110nM). Displays modest brain penetration in vivo.

    • Chemical Name: 2-(4,4-Difluoro-1-piperidinyl)-6-methoxy-N-[1-(1-methylethyl)-4-piperidinyl]-7-[3-(1-pyrrolidinyl)propoxy]-4-quinazolinamine
    • Formula: C29H44F2N6O2
    • CAS Number: 1481677-78-4
    • Solubility: Soluble to 100mM in DMSO and to 50mM in 1eq. HCl
    • Purity: >99

  • Description & Specifications

Related Products

Product Content Feedback

We continue to work to improve your shopping experience and your feedback regarding this content is very important to us. Please use the form below to provide feedback related to the content on this product.

Product Title

By clicking Submit, you acknowledge that you may be contacted by Fisher Scientific in regards to the feedback you have provided in this form. We will not share your information for any other purposes. All contact information provided shall also be maintained in accordance with our Privacy Policy.

Cancel Submit