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UNC 0646, Tocris Bioscience™

Catalog Number 434250
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Quantity:
10 mg
50 mg
This item is not returnable. View return policy
1320288-17-2
C36H59N7O2
621.915
OUKWLRHRXOPODD-UHFFFAOYSA-N
1-cyclohexyl-piperidin-4-yl-2-4-isopropyl-1,4 diazepan-1-yl-6-methoxy-7-3-piperidin-1-yl-propoxy-quinazolin-4-yl-amine, n-1-cyclohexylpiperidin-4-yl-2-4-isopropyl-1,4-diazepan-1-yl-6-methoxy-7-3-piperidin-1-yl propoxy quinazolin-4-amine, n-1-cyclohexyl-4-piperidinyl-2-hexahydro-4-1-methylethyl-1h-1,4-diazepin-1-yl-6-methoxy-7-3-1-piperidinyl propoxy-4-quinazolinamine, n-1-cyclohexylpiperidin-4-yl-6-methoxy-7-3-piperidin-1-ylpropoxy-2-4-propan-2-yl-1,4-diazepan-1-yl quinazolin-4-amine, n-1-cyclohexylpiperidin-4-yl-6-methoxy-7-3-piperidin-1-yl propoxy-2-4-propan-2-yl-1,4-diazepan-1-yl quinazolin-4-amine
53315882
N-(1-cyclohexylpiperidin-4-yl)-6-methoxy-7-(3-piperidin-1-ylpropoxy)-2-(4-propan-2-yl-1,4-diazepan-1-yl)quinazolin-4-amine
CC(C)N1CCCN(CC1)C2=NC3=CC(=C(C=C3C(=N2)NC4CCN(CC4)C5CCCCC5)OC)OCCCN6CCCCC6
This item is not returnable. View return policy
1320288-17-2
C36H59N7O2
621.915
OUKWLRHRXOPODD-UHFFFAOYSA-N
1-cyclohexyl-piperidin-4-yl-2-4-isopropyl-1,4 diazepan-1-yl-6-methoxy-7-3-piperidin-1-yl-propoxy-quinazolin-4-yl-amine, n-1-cyclohexylpiperidin-4-yl-2-4-isopropyl-1,4-diazepan-1-yl-6-methoxy-7-3-piperidin-1-yl propoxy quinazolin-4-amine, n-1-cyclohexyl-4-piperidinyl-2-hexahydro-4-1-methylethyl-1h-1,4-diazepin-1-yl-6-methoxy-7-3-1-piperidinyl propoxy-4-quinazolinamine, n-1-cyclohexylpiperidin-4-yl-6-methoxy-7-3-piperidin-1-ylpropoxy-2-4-propan-2-yl-1,4-diazepan-1-yl quinazolin-4-amine, n-1-cyclohexylpiperidin-4-yl-6-methoxy-7-3-piperidin-1-yl propoxy-2-4-propan-2-yl-1,4-diazepan-1-yl quinazolin-4-amine
53315882
N-(1-cyclohexylpiperidin-4-yl)-6-methoxy-7-(3-piperidin-1-ylpropoxy)-2-(4-propan-2-yl-1,4-diazepan-1-yl)quinazolin-4-amine
CC(C)N1CCCN(CC1)C2=NC3=CC(=C(C=C3C(=N2)NC4CCN(CC4)C5CCCCC5)OC)OCCCN6CCCCC6

Description

Potent and selective G9a and GLP inhibitor

Potent and selective inhibitor of the homologous protein lysine methyltransferases, G9a and GLP (IC50 values are 6 nM and 15 nM for G9a and GLP, respectively). Potently blocks G9a/GLP methyltransferase activity in cells (IC50 = 10 nM in MCF7 cells); exhibits low cellular toxicity (EC50 = 4.7 μM in MCF7 cells). Selective for G9a/GLP over a range of other protein lysine methyltransferases and protein arginine methyltransferases.
Quantity 50 mg
Formula Weight 621.9
Percent Purity >99%
Chemical Name or Material UNC 0646

Safety and Handling

Recommended Storage Store at +4°C
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