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Tocris Bioscience™ UNC 1999

Potent and selective EZH2/EZH1 inhibitor

Supplier:  Tocris Bioscience™ 4904/50

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Catalog No. 49-045-0


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Description

Description

UNC 1999 is a potent and SAM-competitive EZH2/EZH1 lysine methyltransferase inhibitor (IC50 values are 10 and 45 nM, respectively). Selective for EZH2/EZH1 over a panel of other methyltransferases and non-epigenetic targets. Reduces H3K27me3 levels in vitro. Prolongs survival of MLL-AF9 bearing mice. Orally bioavailable.

Negative Control also available.

Specifications

Specifications

>99%
UNC 1999
UNC 1999
50 mg
569.74
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For Research Use Only