Tocris UNC 1999
Potent and selective EZH2/EZH1 inhibitor
Manufacturer: Tocris 4904/50
DescriptionPotent and SAM-competitive EZH2/EZH1 lysine methyltransferase inhibitor (IC50 values are 2 and 45nM respectively). Selective for EZH2/EZH1 over a panel of other methyltransferases and non-epigenetic targets. Reduces H3K27me3 levels in vitro. Prolongs survival of MLL-AF9 bearing mice. Orally bioavailable.
- Chemical Name: N-[(1,2-Dihydro-6-methyl-2-oxo-4-propyl-3-pyridinyl)methyl]-1-(1-methylethyl)-6-[6-[4-(1-methylethyl)-1-piperazinyl]-3-pyridinyl]-1H-indazole-4-carboxamide
- Formula: C33H43N7O2
- CAS Number: 1431612-23-5
- Solubility: Soluble to 100mM in 1eq. HCl and to 20mM in DMSO
- Purity: >99
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