Tocris™ UNC 1999

Potent and selective EZH2/EZH1 inhibitor

Manufacturer: Tocris™ 4904/10

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Catalog No. 49-041-0

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For Research Use Only


    Inhibitors UNC 1999
    Purity >99
    Molecular Weight 569.74
    Quantity 10mg
    Product Type UNC 1999

    Potent and SAM-competitive EZH2/EZH1 lysine methyltransferase inhibitor (IC50 values are 2 and 45nM respectively). Selective for EZH2/EZH1 over a panel of other methyltransferases and non-epigenetic targets. Reduces H3K27me3 levels in vitro. Prolongs survival of MLL-AF9 bearing mice. Orally bioavailable.

    • Chemical Name: N-[(1,2-Dihydro-6-methyl-2-oxo-4-propyl-3-pyridinyl)methyl]-1-(1-methylethyl)-6-[6-[4-(1-methylethyl)-1-piperazinyl]-3-pyridinyl]-1H-indazole-4-carboxamide
    • Formula: C33H43N7O2
    • CAS Number: 1431612-23-5
    • Solubility: Soluble to 100mM in 1eq. HCl and to 20mM in DMSO
    • Purity: >99

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