Tocris UNC 3230
Potent and selective PIP5K1C inhibitor; antinociceptive
Manufacturer: Tocris 5271/50
DescriptionPotent and selective PIP5K1C inhibitor (IC50 = 41nM). Exhibits selectivity for PIP5K1C over PIP5K1A, the PI 3-kinase family and a panel of other kinases. Reduces PIP2 levels and LPA-induced calcium signaling in dorsal root ganglia (DRG) neurons in vitro. Reduces nociception in mouse models of chronic pain.
- Chemical Name: 5-[(Cyclohexylcarbonyl)amino]-2-(phenylamino)-thiazolecarboxamide
- Formula: C17H20N4O2S
- CAS Number: 1031602-63-7
- Solubility: Soluble to 100mM in DMSO
- Purity: >99
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