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UNC5B Rabbit anti-Mouse, Rat, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA549453

Catalog No. PA549453

This item has been discontinued by the manufacturer and is no longer available. Please call customer service for assistance: 1-800-766-7000.


Description

Description

Receptor for netrin required for axon guidance. Mediates axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding. Axon repulsion in growth cones may be caused by its association with DCC that may trigger signaling for repulsion. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand. Mediates apoptosis by activating DAPK1. In the absence of NTN1, activates DAPK1 by reducing its autoinhibitory phosphorylation at Ser-308 thereby increasing its catalytic activity.
Specifications

Specifications

UNC5B
Polyclonal
PBS with 0.09% sodium azide
Q8K1S3, O08722
Netrin receptor UNC5B, Protein unc-5 homolog 2, Protein unc-5 homolog B, p53-regulated receptor for death and life protein 1, UNC5B, P53RDL1, UNC5H2
Rabbit
IgG
400 μL
-20° C, Avoid Freeze/Thaw Cycles
Primary
107449, 60630
Western Blot
Unconjugated
Unc5b
Liquid
UNC5B
KLH conjugated synthetic peptide between 507-541 amino acids from the Central region of human UNC5B.
Antigen affinity chromatography
RUO
Antibody
Polyclonal
Mouse, Rat
Documents
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