USP13 Mouse anti-Human, Clone: OTI4G1, Invitrogen
Mouse Monoclonal Antibody
Manufacturer: Invitrogen MA524907
DescriptionModification of target proteins by ubiquitin participates in a wide array of biological functions. Proteins destined for degradation or processing via the 26 S proteasome are coupled to multiple copies of ubiquitin. However, attachment of ubiquitin or ubiquitin-related molecules may also result in changes in subcellular distribution or modification of protein activity. An additional level of ubiquitin regulation, deubiquitination, is catalyzed by proteases called deubiquitinating enzymes, which fall into four distinct families. Ubiquitin C-terminal hydrolases, ubiquitin-specific processing proteases (USPs),1 OTU-domain ubiquitin-aldehyde-binding proteins, and Jab1/Pad1/MPN-domain-containing metallo-enzymes. Among these four families, USPs represent the most widespread and represented deubiquitinating enzymes across evolution. USPs tend to release ubiquitin from a conjugated protein. They display similar catalytic domains containing conserved Cys and His boxes but divergent N-terminal and occasionally C-terminal extensions, which are thought to function in substrate recognition, subcellular localization, and protein-protein interactions.
|PBS with 1% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3|
|ISOT3, IsoT-3, deubiquitinating enzyme 13, isopeptidase T-3, ubiquitin carboxyl-terminal hydrolase 13, ubiquitin specific protease 13 (isopeptidase T-3), ubiquitin thioesterase 13, ubiquitin thiolesterase 13, ubiquitin-specific-processing protease 13|
|-20° C, Avoid Freeze/Thaw Cycles|
|Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot|
|Full-length protein expressed in 293T cell transfected with human USP13 expression vector|
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