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USP13 Mouse anti-Human, Clone: OTI4G1, Invitrogen™

Mouse Monoclonal Antibody

Manufacturer:  Invitrogen MA524907

Catalog No. PIMA524907


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Description

Description

Modification of target proteins by ubiquitin participates in a wide array of biological functions. Proteins destined for degradation or processing via the 26 S proteasome are coupled to multiple copies of ubiquitin. However, attachment of ubiquitin or ubiquitin-related molecules may also result in changes in subcellular distribution or modification of protein activity. An additional level of ubiquitin regulation, deubiquitination, is catalyzed by proteases called deubiquitinating enzymes, which fall into four distinct families. Ubiquitin C-terminal hydrolases, ubiquitin-specific processing proteases (USPs),1 OTU-domain ubiquitin-aldehyde-binding proteins, and Jab1/Pad1/MPN-domain-containing metallo-enzymes. Among these four families, USPs represent the most widespread and represented deubiquitinating enzymes across evolution. USPs tend to release ubiquitin from a conjugated protein. They display similar catalytic domains containing conserved Cys and His boxes but divergent N-terminal and occasionally C-terminal extensions, which are thought to function in substrate recognition, subcellular localization, and protein-protein interactions.
Specifications

Specifications

USP13
Monoclonal
0.9 mg/mL
PBS with 1% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3
Q92995
ISOT3, IsoT-3, deubiquitinating enzyme 13, isopeptidase T-3, ubiquitin carboxyl-terminal hydrolase 13, ubiquitin specific protease 13 (isopeptidase T-3), ubiquitin thioesterase 13, ubiquitin thiolesterase 13, ubiquitin-specific-processing protease 13
Mouse
IgG1
100 μL
-20° C, Avoid Freeze/Thaw Cycles
Primary
8975
Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot
OTI4G1
Unconjugated
USP13
Liquid
USP13
Full-length protein expressed in 293T cell transfected with human USP13 expression vector
Affinity Chromatography
RUO
Antibody
Monoclonal
Human
Documents
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