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USP14 Mouse anti-Human, Mouse, Rat, Clone: 889CT6.2.1, Invitrogen™

Mouse Monoclonal Antibody

Manufacturer:  Invitrogen MA524727

Catalog No. PIMA524727


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Description

Description

Modification of target proteins by ubiquitin participates in a wide array of biological functions. Proteins destined for degradation or processing via the 26 S proteasome are coupled to multiple copies of ubiquitin. However, attachment of ubiquitin or ubiquitin-related molecules may also result in changes in subcellular distribution or modification of protein activity. An additional level of ubiquitin regulation, deubiquitination, is catalyzed by proteases called deubiquitinating enzymes, which fall into four distinct families. Ubiquitin C-terminal hydrolases, ubiquitin-specific processing proteases (USPs),1 OTU-domain ubiquitin-aldehyde-binding proteins, and Jab1/Pad1/MPN-domain-containing metallo-enzymes. Among these four families, USPs represent the most widespread and represented deubiquitinating enzymes across evolution. USPs tend to release ubiquitin from a conjugated protein. They display similar catalytic domains containing conserved Cys and His boxes but divergent N-terminal and occasionally C-terminal extensions, which are thought to function in substrate recognition, subcellular localization, and protein-protein interactions.
Specifications

Specifications

USP14
Monoclonal
0.5 mg/mL
PBS with 0.09% sodium azide
P54578, Q9JMA1
Ubiquitin carboxyl-terminal hydrolase 14, Deubiquitinating enzyme 14, Ubiquitin thioesterase 14, Ubiquitin-specific-processing protease 14, USP14, TGT
Mouse
IgG1
400 μL
-20° C, Avoid Freeze/Thaw Cycles
Primary
291796, 59025, 9097
Western Blot
889CT6.2.1
Unconjugated
USP14
Liquid
USP14
Purified His-tagged USP14 protein
Protein G
RUO
Antibody
Monoclonal
Human, Mouse, Rat
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