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USP5 Rabbit anti-Human, Mouse, Rat, Polyclonal, Proteintech Non-distribution product as customer accommodation.

Rabbit Polyclonal Antibody

Manufacturer:  Proteintech Group IncSupplier Diversity Partner 151581AP

Catalog No. 50-173-0028


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Description

Description

USP5 (ubiquitin carboxyl-terminal hydrolase 5) cleaves linear and branched multiubiquitin polymers with a marked preference for branched polymers. It is involved in uchored Lys-48-linked polyubiquitin disassembly, and also binds linear and Lys-63 linked polyubiquitin with a lower affinity. Knock-down of USP5 causes the accumulation of p53/TP53 and an increase in p53/TP53 transcriptional activity because the uchored polyubiquitin that accumulates is able to compete with ubiquitinated p53/TP53 but not with MDM2 for proteasomal recognition.
Specifications

Specifications

USP5
0.27 mg/mL
PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
P45974, P56399
Deubiquitinating enzyme 5, Isopeptidase T, ISOT, Ubiquitin thiolesterase 5, USP5
Rabbit
IgG
150 μL
-20°C
Primary
22225, 297593, 8078
Immunoprecipitation, Western Blot
Unconjugated
USP5
Liquid
USP5
USP5 Fusion Protein Ag7252
Antigen Affinity Chromatography
RUO
Antibody
Polyclonal
Human, Mouse, Rat
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