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USP5 Mouse anti-Canine, Human, Non-human primate, Rat, Clone: OTI2E3, Invitrogen™

Mouse Monoclonal Antibody

Manufacturer:  Invitrogen MA525140

Catalog No. PIMA525140


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Description

Description

USP5 (ubiquitin carboxyl-terminal hydrolase 5) cleaves linear and branched multiubiquitin polymers with a marked preference for branched polymers. It is involved in uchored Lys-48-linked polyubiquitin disassembly, and also binds linear and Lys-63 linked polyubiquitin with a lower affinity. Knock-down of USP5 causes the accumulation of p53/TP53 and an increase in p53/TP53 transcriptional activity because the uchored polyubiquitin that accumulates is able to compete with ubiquitinated p53/TP53 but not with MDM2 for proteasomal recognition.
Specifications

Specifications

USP5
Monoclonal
0.45 mg/mL
PBS with 1% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3
P45974
ISOT, deubiquitinating enzyme 5, isopeptidase T, ubiquitin carboxyl-terminal hydrolase 5, ubiquitin isopeptidase T, ubiquitin specific protease 5 (isopeptidase T), ubiquitin thioesterase 5, ubiquitin thiolesterase 5, ubiquitin-specific protease-5 (ubiquitin isopeptida
Mouse
IgG2a
100 μL
-20° C, Avoid Freeze/Thaw Cycles
Primary
297593, 486718, 714032, 8078
Immunohistochemistry (Paraffin), Western Blot
OTI2E3
Unconjugated
USP5
Liquid
USP5
Full length human recombit protein of USP5 produced in HEK293T cell
Affinity Chromatography
RUO
Antibody
Monoclonal
Canine, Human, Non-human primate, Rat
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