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USP7 Rabbit anti-Human, Mouse, Rat, Unconjugated, Clone: ARC0777, Invitrogen™

Rabbit Monoclonal Antibody

Manufacturer:  Invitrogen MA535369

Catalog No. PIMA535369


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Description

Description

USP7 or HAUSP is a ubiquitin specific protease or a deubiquitylating enzyme that cleaves ubiquitin from its substrates. Since ubiquitylation (polyubiquitination) is most commonly associated with the stability and degradation of cellular proteins, HAUSP activity generally stabilizes its substrate proteins. HAUSP is most popularly known as a direct antagonist of Mdm2, the E3 ubiquitin ligase for the tumor suppressor protein, p53. Normally, p53 levels are kept low in part due to Mdm2-mediated ubiquitylation and degradation of p53. Interestingly, in response to oncogenic insults, HAUSP can deubiquitinate p53 and protect p53 from Mdm2-mediated degradation, indicating that it may possess a tumor suppressor function for the immediate stabilization of p53 in response to stress. Another important role of HAUSP function involves the oncogenic stabilization of p53. Oncogenes such as Myc and E1A are thought to activate p53 through a p19 alternative reading frame (p19ARF, also called ARF)-dependent pathway, although some evidence suggests ARF is not essential in this process. An intriguing possibility is that HAUSP provides an alternative pathway for safeguarding the cell against oncogenic insults.
Specifications

Specifications

USP7
ARC0777
PBS with 50% glycerol and 0.2% sodium azide; pH 7.3
Q4VSI4, Q6A4J8, Q93009
2210010O09Rik; AA409944; AA617399; AU019296; AW548146; C80752; Deubiquitinating enzyme 7; Hausp; Herpesvirus-associated ubiquitin-specific protease; mHAUSP; rHAUSP; TEF1; Ubiquitin carboxyl-terminal hydrolase 7; Ubiquitin thioesterase 7; Ubiquitin-specific-processing protease 7; UBP; USP7
Rabbit
IgG
100 μL
-20°C, Avoid Freeze/Thaw Cycles
Primary
252870, 360471, 7874
Western Blot
Unconjugated
USP7
Liquid
USP7
A synthesized peptide derived from human HAUSP / USP7
Protein A
RUO
Antibody
Monoclonal
Human, Mouse, Rat
SDS
Documents
Product Certifications
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