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Urotensin II Receptor Rabbit anti-Human, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA550506

Catalog No. PA550506


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Description

Description

The antibody detects endogenous levels of total UTS2R / GPR14 protein.

The Urotensin-II receptor has been reported to be expressed at high levels in the heart and pancreas and also in artery and smooth muscle. Low transcript levels have been identified in brain, particularly in thalamus, and superior occipital gyrus. G-protein Coupled Receptors (GPCRs) comprise one of the largest families of signaling molecules with more than a thousand members currently predicted to exist. All GPCRs share a structural motif consisting of seven membrane-spanning helices, and exist in both active and inactive forms. An array of activating ligands participate in the conformation of GPCRs which leads to signaling via G-proteins and downstream effectors. Ongoing studies have also shown the vast series of reactions which participate in the negative regulation of GPCRs. This ""turn-off"" activity has tremendous implications for the physiological action of the cell, and continues to drive pharmacological research for new drug candidates. Two blockbuster drugs which have been developed as GPCR-targeted pharmaceuticals are Zyprexa (Eli Lilly) and Claritin (Schering-Plough) which have multi-billion dollar shares of the mental health and allergy markets, respectively.
Specifications

Specifications

Urotensin II Receptor
Polyclonal
Unconjugated
UTS2R
Liquid
UTS2R
Synthetic peptide corresponding to a region derived from internal residues of human urotensin 2 receptor
Antigen affinity chromatography
RUO
Antibody
Polyclonal
Human
Western Blot
0.8 mg/mL
PBS with 50% glycerol and 0.05% sodium azide; pH 7.3
Q9UKP6
GPR14
Rabbit
IgG
100 μL
-20°C
Primary
2837
Documents
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