Vβ4 T-Cell Receptor Rat anti-Mouse, Brilliant Violet 786, Clone: KT4, BD Optibuild™
Rat Monoclonal Antibody
Manufacturer: BD Biosciences 743024
The KT4 antibody specifically recognizes the Vβ4 T-cell Receptor (TCR) of mice having the a ( e.g /., C57BR, C57L, SJL, SWR), b ( e.g /., A, AKR, BALB/c, CBA, C3H/He, C57BL, C58, DBA/1, DBA/2), and c ( e.g /., RIII) haplotypes of the Tcrb /gene complex. Vβ4 TCR-bearing cells are among the CD4+ autoreactive T cells which induce autoimmune thyroiditis after elimination of regulatory (CD5-bright) T-cell subsets. Plate-bound KT4 antibody activates Vβ4 TCR-bearing T cells.The antibody was conjugated to BD Horizon™ BV786 which is part of the BD Horizon Brilliant™ Violet family of dyes. This dye is a tandem fluorochrome of BD Horizon BV421 with an Ex Max of 405nm and an acceptor dye with an Em Max at 786nm. BD Horizon BV786 can be excited by the violet laser and detected in a filter used to detect Cy™7-like dyes (eg, 780/60nm filter). BV786 is a tandem fluorochrome of BD Horizon BV421 and an acceptor dye with an emission maximum at 786 nm. BV786 offers a bright choice for the 6th detector off the violet laser.
|Vβ4 T-Cell Receptor|
|Brilliant Violet 786|
|TCR V beta 4, TCR Vβ4|
|KT4 B10.D2 mouse T-cell clone I3|
|Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.|
|Aqueous buffered solution containing ≤0.09% sodium azide.|
|Rat SD, also known as Sprague-Dawley (outbred) IgG2b κ|
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