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TCR V beta 2 Rat anti-Mouse, FITC, Clone: B20.6, eBioscience™ Non-distribution product as customer accommodation.

Rat Monoclonal Antibody

$108.00 - $259.00

Specifications

Antigen TCR V beta 2
Clone B20.6
Target Species Mouse
Conjugate FITC
Isotype IgG2a, kappa
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Products 2
Catalog Number Mfr. No. Quantity Price Quantity & Availability  
Catalog Number Mfr. No. Quantity Price Quantity & Availability  
50-245-242 Non-distribution product as customer accommodation.
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Invitrogen
11580480
25 μg Each for $108.00
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50-245-243 Non-distribution product as customer accommodation.
View Documents
Invitrogen
11580482
100 μg Each for $259.00
Add to cart
 
Description

Description

Description: The B20.6 monoclonal antibody reacts with the mouse T-cell receptor (TCR) V beta 2 chain. Neonatal T cells which express V beta 2, and are exposed to the Balb/cV virus are eliminated during negative selection, while adult T cells expressing V beta 2 and exposed to the Balb/cV virus are clonally expanded. Applications Reported: This B20.6 antibody has been reported for use in flow cytometric analysis. Applications Tested: This B20.6 antibody has been tested by flow cytometric analysis of lymph node cells. This can be used at less than or equal to 1 µg per test. A test is defined as the amount (µg) of antibody that will stain a cell sample in a final volume of 100 µL. Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test. It is recommended that the antibody be carefully titrated for optimal performance in the assay of interest. Excitation: 488 nm; Emission: 520 nm; Laser: Blue Laser. Filtration: 0.2 µm post-manufacturing filtered.

The ability of T cell receptors (TCR) to discriminate foreign from self-peptides presented by major histocompatibility complex (MHC) class II molecules is essential for an effective adaptive immune response. TCR recognition of self-peptides has been linked to autoimmune disease. Mutant self-peptides have been associated with tumors. Engagement of TCRs by a family of bacterial toxins know as superantigens has been responsible for toxic shock syndrome. Autoantibodies to V beta segments of T cell receptors have been isolated from patients with rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE). The autoantibodies block TH1-mediated inflammatory autodestructive reactions and are believed to be a method by which the immune system compensates for disease. Most human T cells express the TCR alpha-beta and either CD4 or CD8 molecule (single positive, SP). A small number of T cells lack both CD4 and CD8 (double negative, DN). Increased percentages of alpha-beta DN T cells have been identified in some autoimmune and immunodeficiency disorders. Gamma-delta T cells are primarily found within the epithelium. They show less TCR diversity and recognize antigens differently than alpha-beta T cells. Subsets of gamma-delta T cells have shown antitumor and immunoregulatory activity.
Specifications

Specifications

TCR V beta 2
Mouse
IgG2a, kappa
Monoclonal
Liquid
Antibody
4° C, store in dark, DO NOT FREEZE!
B20.6
FITC
Flow Cytometry
Primary
Monoclonal
PBS with 0.1% gelatin and 0.09% sodium azide; pH 7.2
RUO

For Research Use Only.

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