VANGL1 Mouse anti-Human, Clone: CL0241, Invitrogen
Mouse Monoclonal Antibody
Manufacturer: Invitrogen MA524592
Immunogen sequence: DTESTYSGYS YYSSHSKKSH RQGERTRERH KSPRNKDGRG SEKSVTIQPP TGEPLLGNDS TRTEEVQDDN WGETTTAITG TSEHSISQED IARISKDMED SVGLDCKRY Highest antigen sequence identity to the following orthologs: Mouse - 95%, Rat - 95%.Vang-like 1 protein is a novel human homologue of Drosophila Van Gogh/Strabismus. The Vang-like 1 gene consists of at least 7 exons, and encodes a protein with four transmembrane domains and the C-terminal Ser/Thr-X-Val motif. Studies shows that the expression of the protein is significantly up-regulated in gastric cancer cell lines MKN28, MKN74, pancreatic cancer cell lines BxPC-3, PSN-1 and Hs766T. The protein may serve as an effector mediating the intestinal trefoil factor (ITF) healing response of the intestinal mucosa. The protein also serves as a diagnostic marker for hepatocellular carcinoma as well as a potential molecular target for development of novel therapeutic drugs. The pathological role of the protein has been identified in neural tube defects (NTD). Human Vang-like 1 gene maps to chromosome 1p11-p13.1.
|PBS with 40% glycerol and 0.02% sodium azide; pH 7.2|
|KITENIN, LPP2, STB2, STBM2, KAI1 C-terminal interacting tetraspanin, loop-tail protein 2 homolog, strabismus 2, van Gogh-like protein 1, vang-like protein 1|
|Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.|
|Recombit protein corresponding to Human VANGL1|
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