Versican Mouse anti-Human, Mouse, Rat, Clone: S351-23, Invitrogen
Mouse Monoclonal Antibody
Manufacturer: Invitrogen MA527638
DescriptionVersican (chondroitin sulfate proteoglycan 2) is a large extracellular matrix proteoglycan involved in cell growth and differentiation. Important as a structural molecule, versican creates loose and hydrated matrices during key events in development and disease. The protein contains hyaluronic acid and glycosminoglycan-binding domains, epidermal growth factor-like repeats, a Lectinlike sequence and a complement regulatory protein-like domain. Splice variants differ greatly in length anddegree of modification by glycoaminoglycan chains. Accumulation around smooth muscle cells in lesions of athero-sclerosis suggests a role for versican in atherogenesis. Versican, differentially expressed in human melanoma, plays a role in tumor development and may be a reliable marker for clinical diagnosis. The organization of HA- and versican-rich pericellular matrices may faciliatate migration and mitosis by diminishing cell surface adhesivity and affecting cell shape through steric exclusion and the viscous properties of HA proteoglycan gels.
|PBS with 50% glycerol and 0.1% sodium azide; pH 7.4|
|P13611, Q62059, Q9ERB4|
|Chondroitin sulfate proteoglycan 2, CSPG2, ERVR, GHAP, PG-M, VCAN, Chondroitin sulfate proteoglycan 2, Chondroitin sulfate proteoglycan core protein 2, Glial hyaluronate binding protein, Glial hyaluronate-binding protein, Large fibroblast proteoglycan, Large fibroblast proteoglycan, PGM, V1 Neo, Versican core protein, Versican proteoglycan, Versican V0, WGN 1, WGN, WGN1|
|114122, 13003, 1462|
|Immunocytochemistry, Immunofluorescence, Western Blot|
|Fusion protein amino acids 362-585 (glycosaminoglycan alpha domain) of mouse Versican core protein|
|Human, Mouse, Rat|
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