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Versican Mouse anti-Human, Mouse, Rat, Clone: S351-23, Invitrogen™

Mouse Monoclonal Antibody

Manufacturer:  Invitrogen MA527638

Catalog No. PIMA527638


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Description

Description

Versican (chondroitin sulfate proteoglycan 2) is a large extracellular matrix proteoglycan involved in cell growth and differentiation. Important as a structural molecule, versican creates loose and hydrated matrices during key events in development and disease. The protein contains hyaluronic acid and glycosminoglycan-binding domains, epidermal growth factor-like repeats, a Lectinlike sequence and a complement regulatory protein-like domain. Splice variants differ greatly in length anddegree of modification by glycoaminoglycan chains. Accumulation around smooth muscle cells in lesions of athero-sclerosis suggests a role for versican in atherogenesis. Versican, differentially expressed in human melanoma, plays a role in tumor development and may be a reliable marker for clinical diagnosis. The organization of HA- and versican-rich pericellular matrices may faciliatate migration and mitosis by diminishing cell surface adhesivity and affecting cell shape through steric exclusion and the viscous properties of HA proteoglycan gels.
Specifications

Specifications

Versican
Monoclonal
1 mg/ml
PBS with 50% glycerol and 0.1% sodium azide; pH 7.4
P13611, Q62059, Q9ERB4
Chondroitin sulfate proteoglycan 2, CSPG2, ERVR, GHAP, PG-M, VCAN, Chondroitin sulfate proteoglycan 2, Chondroitin sulfate proteoglycan core protein 2, Glial hyaluronate binding protein, Glial hyaluronate-binding protein, Large fibroblast proteoglycan, Large fibroblast proteoglycan, PGM, V1 Neo, Versican core protein, Versican proteoglycan, Versican V0, WGN 1, WGN, WGN1
Mouse
IgG1
100 μg
-20°C
Primary
114122, 13003, 1462
Immunocytochemistry, Immunofluorescence, Western Blot
S351-23
Unconjugated
VCAN
Liquid
VCAN
Fusion protein amino acids 362-585 (glycosaminoglycan alpha domain) of mouse Versican core protein
Protein G
RUO
Antibody
Monoclonal
Human, Mouse, Rat
Documents
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