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Tocris Bioscience™ VH 298 Available on GSA/VA Contract for Federal Government customers only.

High-affinity inhibitor of VHL

$259.00 - $1095.00


Products 2
Catalog Number Mfr. No. Quantity Price Quantity & Availability  
Catalog Number Mfr. No. Quantity Price Quantity & Availability  
61-561-0 Available on GSA/VA Contract for Federal Government customers only. View Documents Tocris Bioscience™
6156/10
Each for $259.00
Add to cart
 
61-565-0 View Documents Tocris Bioscience™
6156/50
Each for $1,095.00
Add to cart
 
Description

Description

High-affinity inhibitor of E3 ubiquitin ligase VHL (Kd = 80-90 nM). Blocks interaction between VHL and HIF-α downstream of HIF-α hydroxylation, initiating hypoxic response. Results in time- and concentration-dependent accumulation of hydroxylated HIF-α, and upregulates mRNA and protein levels of HIF target genes, with similar transcriptional profile to hypoxia. Cell permeable.

Negative control cis VH 298 also available.

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For Research Use Only

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